Slide 2: visual deign consistency - balance in slide - bacground of research eminar programmes Slide 3: resolution of figure too low - AMR burden is largely decreaing Slide 6: figure resolution too low - but you should include specifics of Canada’s implementation too - Focus on biases Slide 8: AMR genomics slide feels a bit of non-sequitur Slide 9: Need to explain AMR genomics - not clear where determinants are coming from Slide 10: Explain specific examples? Slide 12: slide a mess - line broken thing not centralised Slide 13: ordering is bit messy Slide 14: low resolution figure - doesn’t add anything Slide 15: Attributable or associated burden? 32-highest burden pathogens across profiles. Slide is a mess Slide 16 - your finding is capacity is low - don’t spoil it Slide 17: axes labels missing or messy. Species names should be italicised Slide 19: maps way too small - why 2018 - can you justify this what is the basis for this leading to a surge of funding Slide 20: Don’t try and dump Slide 22: way too much data for 1 sslide - pick one of SRA or genomic data Slide 23: log-log power laws - conclusion opposite of what you showed Slide 24: too much text Slide 25 Slide 26: not looking at analyses category to understand why its novel but to understand why it is high risk Slide 27: shouldhappen much earlier on Slide 28: primary curation databases Slide 29: flow doesn’t make sense Slide 30: explain your role Slide 31: ITALICS Slide 32: efflux isn’t a drug class. You need to explain AMRrules better and what you actually contributed Slide 36: Develop you tool - don’t mention evANI beyond “building on evANI” Slide 39: don’t talk about work you didn’t do just use explain the methods sand then explain you used evANI to justify your selection of method Slide 40: How much data are you talking about - justify this… Slide 41: resolution of figure - very messy figure…AllTheBacteria, NCBI Pathogens, Local Databases should be introduced… ICE genes? Query line should be included… Slide 43: need more details about HOW you are going to do these next steps - what do you mean by validation, what does that look like? Are you going to make this problem simpler… Report in the context of SHL… Messy slide… DHW NS AMRAANI pillar Slide 44: next steps need explained better and visualisations included Slide 46: Question slide resolutions

Framing should be: amr problem -> need to more effectively use drugs/surveill -> one solution to this is AMR genomics -> AMR genomics has challenges in contextualisations -> we want to develop automated tools to do this contexualisation -> to do this we need relevant data -> so what data is present? and pick one of genomes sor reads

Don’t dump all your data/plots make an actual argument - throughline

Minimise how much you are talking about work you didn’t do…

Need to actually make a case for your data/analysis

Chapter 1: Chapter 2: